In the preceding paper, the development of a Miracil D-resistant sublime of mouse leukemia L1210 has been described (3). In view of its biologic stability and other characteristics, it was of interest to inquire into reasons
نویسندگان
چکیده
D-resistant sublime of mouse leukemia L1210 has been described (3). In view of its biologic stability and other characteristics, it was of interest to inquire into reasons for the failure of this subline to respond to this agent. The present experiments were designed to affirm or eliminate one possible mechanism of resistance (cf. Ref. 4), i.e., reduced uptake of Miracil D by the resistant cells upon exposure to the drug. A preliminary report of some of the results has been made (2).
منابع مشابه
Development and Properties of Mouse Leukemia L1210 Resistant to Miracil D.
diethylaminoethylamino 4 methyl 10 thiaxanthenone (Miracil D, Niodin, lucanthone) has a wide spectrum of carcinostatic effectiveness against a variety of mouse tumors at nontoxic dosage levels (5). One of the most responsive tumors was leukemia L1210 ascites, a test sys tem which has proven relatively refractory to carcino static agents in general (3). The mechanism of action of this drug, whic...
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